Scientists have developed an approach to creating treatments for osteoporosis and autoimmune diseases that may avoid the risk of infection and cancer posed by some current medications.
Researchers at Washington University School of Medicine in St. Louis redesigned a molecule that controls immune cell activity, changing the molecule’s target and altering the effects of the signal it sends.
Current treatments for bone loss and autoimmune disorders block these molecules and their signals indiscriminately, which over time increases the risk of infections and cancer. The new approach may let scientists selectively block the bad signals that cause or contribute to disease and enhance good signals that defend the body against cancer and infections such as tuberculosis.
Featured article originally published at Washington University Newsroom: Discovery may lead to better treatments for autoimmune diseases, bone loss