Division of Geriatrics & Nutritional Science
Mailing Address 660 S. Euclid Ave.
Campus Box 8031
St. Louis, MO 63110
Office Location 203 West Building
Office Phone (314) 362-8963
Lab Phone (314) 362-8994
Fax (314) 362-8230
Metabolic Regulation and Obesity
Signal Transaction/Hormone Action
Category(ies) of Research:
Descriptor of Research:
We are interested in the effects of a protein called lipin 1 on liver metabolism in health and disease. Our basic science program is aimed at understanding the molecular mechanisms whereby lipin impacts energy metabolism by using strategies to genetically activate, deactivate, or selectively mutate lipin activity in mice and cultured cells. Through collaborations with other investigators conducting clinical studies, we are also quantifying the expression of lipin and its target genes involved in energy metabolism in normal and diseased liver.