Developmental Biology and Medicine
Mailing Address 660 S. Euclid Ave.
St. Louis, MO 63110
Office Location BJC – Institute of Health
11th Floor, Room 11613
Phone (314) 454-8795
Metabolic Regulation and Obesity
Signal Transduction/Hormone Action
Category(ies) of Research
Descriptor of Research
A main research interest in my lab is to understand the molecular mechanisms of cell differentiation. In particular, we are interested in how developmental signals control the fate of mesenchymal cell types including osteoblasts and adipocytes, both of which have emerged as important regulators of systemic glucose metabolism in recent years. In our studies of Wnt signaling (important regulator of osteoblasts and adipocyte differentiation), we have observed that Wnt proteins acutely reprogram cellular metabolism of glucose, and that the reprogramming is important for subsequent differentiation of the cells, and may be directly responsible for changes in gene expression. A major focus in the lab is to understand how Wnt signaling reprograms cellular metabolism and whether a similar regulation is exerted by other developmental signals.