Geriatrics & Nutritional Science
660 S. Euclid Ave
Campus Box 8031
St. Louis, MO 63110
Phone (314) 362-8554
Overeating has caused obesity and obesity is associated with excess circulating nutrients, lipid accumulation in nonadipose tissue, insulin resistance, arteriosclerosis and cardiomyopathy. However, the association of adiposity and metabolic disease is not absolute. There are metabolically normal obese people and metabolically abnormal lean people. Our work focuses on a set of proteins (the perilipins 3-5) that move from the cytosol to the fat/cytosol interface during feeding induced fat storage. When the nutrient bolus is cleared and fat accumulation slows, these proteins move from the fat/cytosol interface back into the cytosol. We hypothesize that an individual’s complement of these proteins, in part, determines the intracellular fat storage capacity and resistance to overeating driven disease.