Director, Center for Women’s Infectious Disease Research
Mailing Address Campus Box 8230
660 S. Euclid Ave.
St. Louis, MO 63110
Office Location Room 10102
McDonnell Pediatric Research Building
Phone (314) 362-6772
Lab Phone (314) 362-7042
Fax (314) 362-3203
Category(ies) of Research
Descriptor of Research
We are interested in the mechanisms involved in the increased prevalence of urinary tract infection (UTI) in diabetics. To address this issue, we have developed a diabetic mouse model of UTI and are comparing differences in UTI pathogenesis between diabetic and non-diabetic mice in various genetic backgrounds. We have found, in collaboration with Dr. Joel Schilling, an increase in UPEC colonization and resulting inflammation in the kidneys in a pre-diabetic model.