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Steroid Derivatives, Simple Carbohyderates, Fatty Acids and Other Volatizable Analytes

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a.) Cholesterol derivatives

– Zhang J, Dudley-Rucker N, Crowley JR, Lopez-Perez E, Issandou M, Schaffer JE, Ory DS. The steroidal analog GW707 activates the SREBP pathway through disruption of intracellular cholesterol trafficking. J Lipid Res. 2004 45: 223-31. PMID: 14617742.

– Frolov A, Zielinski SE, Crowley JR, Dudley-Rucker N, Schaffer JE, Ory DS. NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols. J Biol Chem. 2003 278: 25517-25. PMID: 12719428.

– Racette SB, Lin X, Lefevre M, Spearie CA, Most MM, Ma L, Ostlund RE Jr. Dose effects of dietary phytosterols on cholesterol metabolism: a controlled feeding study. Am J Clin Nutr. 2010;91:32-8. PMID: 19889819

– Lin X, Ma L, Moreau RA, & Ostlund RE Jr. Glycosidic bond cleavage is not required for phytosteryl glycoside-induced reduction of cholesterol absorption in mice. Lipids. 2011;46:701-8. PMID: 21538209

b.) Polyols

– Stull AJ, Thyfault JP, Haub MD, Ostlund RE Jr, Campbell WW. Relationships between urinary inositol excretions and whole-body glucose tolerance and skeletal muscle insulin receptor phosphorylation. Metabolism. 2008; 57: 1545-51. PMID: 18940392

– Cheang KI, Baillargeon JP, Essah PA, Ostlund RE Jr, Apridonize T, Islam L, Nestler JE. Insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome. Metabolism 2008; 57: 1390-7. PMID: 18803944

c.) Long chain fatty acids

– Chakravarthy MV, Pan Z, Zhu Y, Tordjman K, Schneider JG, Coleman T, Turk J, Semenkovich CF. “New” hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis. Cell Metab. 2005; 1: 309-22. PMID: 16054078

– Schneider JG, Yang Z, Chakravarthy MV, Lodhi IJ, Wei X, Turk J, and Semenkovich CF. Macrophage fatty acid synthase deficiency decreases diet-induced atherosclerosis. J. Biol. Chem. 2010; 285: 23398-409. PMID: 20479009.

d.) Short chain fatty acids

– Samuel BS, Shaito A, Motoike T, Rey FE, Backhed F, Manchester JK, Hammer RE, Williams SC, Crowley J, Yanagisawa M, Gordon JI. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci USA 2008;105: 16767-72. PMID: 18931303

– Crawford PA, Crowley JR, Sambandam N, Muegge BD, Costello EK, Hamady M, Knight R, Gordon JI. Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation. Proc Natl Acad Sci USA 2009; 106: 11276-81. PMID: 19549860

– Xu M, Wang WF, Frontera JR, Neely MC, Lu JJ, Aires D, Hsu FF, Turk J, Swerdlow RH, Carlson SE, & Zhu H. Ncb5or deficiency increases fatty acid catabolism, oxidative stress and sensitivity to saturated fatty acid-induced toxicity. J. Biol. Chem. 2011; 286: 11141-54. PMID: 21300801

e.) Oxidized biomolecules

– Zhao Z, Zhang X, Zhao C, Choi J, Shi J, Song K, Turk J, & Ma ZA. Protection of pancreatic β-cells by group VIA phospholipase A2-mediated repair of mitochondrial membrane peroxidation. Endocrinology. 2010; 151: 3038-48. PMID 20463052

– Wang W, Guo Y, Xu M, Huang HH, Novikova L, Larade K, Jiang ZG, Thayer TC, Frontera JR, Aires D, Ding H, Turk J, Mathews CE, Bunn HF, Stehno-Bittel L, Zhu H. Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells. Biochim. Biophys. Acta. 2011; 1812: 1532-1541. PMID: 21839170.


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