Cell Biology and Physiology
660 S Euclid Ave, Campus Box 8228
St Louis, MO 63110
Metabolic Regulation and Obesity
Signal Transduction/Hormone Action
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Descriptor of Research:
The major focus of my research is to develop better therapeutic approaches for Type 1 Diabetes (T1D), without the limitations involved in islet/pancreas transplantation. Subcutaneous transplantation of embryonic brown adipose tissue (BAT) has proven effective in reversing T1D independent of insulin. BAT transplants produce rapid and long-lasting euglycemia in mouse models of T1D both chemically and autoimmune induced, with no need for immunosuppression. Return to normoglycemia correlates with replenishment of healthy white adipose tissue, increased levels of beneficial adipokines and overall decrease of inflammation, while insulin remains consistently low. Thus it appears that a new physiological equilibrium of adipose tissue-derived factors compensates for the lack of insulin. Ongoing work seeks to document the underlying mechanisms of insulin-independent glycemic regulation following BAT transplants, and to customize this approach for human patients through establishing suitable alternatives for embryonic tissue.